Fibronectin and Fibrin Provide a Provisional Matrix for Epidermal Cell Migration During Wound Reepithelialization
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چکیده
منابع مشابه
Fibrinogen and fibronectin as substrates for epidermal cell migration during wound closure.
Pieces of glass coverslip coated with human fibronectin or human fibrinogen were implanted under one margin of a skin wound on adult newt (Notophthalmus viridescens) hind limbs. In contrast to uncoated glass or glass coated with nest serum, bovine serum or bovine serum albumin, glass treated with either fibronectin or fibrinogen supported considerable epidermal cell migration. When optimal amou...
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Epidermal repair during wound healing is under investigation at both the light and electron microscopic levels. Suction-induced subepidermal blisters have been employed to produce two complementary model wound healing systems. These two model systems are: (a) intact subepidermal blisters, and (b) opened subepidermal blisters (the blister roof was removed immediately after induction, leaving an ...
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After injury, the wound space is filled with a fibrin/fibronectin clot containing growth factors released by platelets and monocytes. In response to these factors, fibroblasts migrate into the fibrin clot and contribute to the formation of granulation tissue. The functional mechanisms allowing fibroblasts to leave the collagenous matrix of normal connective tissue and invade the provisional mat...
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Matrix metalloproteinases (MMPs) are extracellular proteases highly expressed at wound sites. However, the precise function of MMPs during reepithelialization in vivo has been elusive in mammalian models because of the high level of redundancy among the 24 mammalian MMPs. For this reason we used Drosophila melanogaster, whose genome encodes only two MMPs-one secreted type (Mmp1) and one membran...
متن کاملFibronectin peptides in cell migration and wound repair.
a serious clinical problem; for example, decubitus and leg ulcers afflict roughly 5 million people in the US alone. Normal wound repair depends on molecules like fibronectin to promote cell adhesion and migration (1). This large adhesive glycoprotein provides a crucial substrate for many forms of cell migration , such as in embryonic migratory pathways and in the provisional matrix of healing w...
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 1982
ISSN: 0022-202X
DOI: 10.1111/1523-1747.ep12500075